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Ceci est le schéma d'un microscope logo de Sophie Pecquet nutritherapeute

Publications scientifiques

[ Sommaire ]
1.  Microbiote Intestinal et Antibiothérapie
2. Immunité des Muqueuses
3. Immunité et Vaccination Orale
4. Allergie et Tolerance Orale aux Antigènes Alimentaires

5. Nutrition Maternelle et Infantile  

 1. Microbiote Intestinal et Antibiothérapie

  • Pecquet S, Andremont A, Tancrède C. Selective antimicrobial modulation of the intestinal tract by Norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora. Antimicrob.Agents Chemother. 29 : 1047-1052, 1986.


  • Pecquet S, Andremont A, Tancrède C. Effect of oral ofloxacin on fecal bacteria in human volunteers. Antimocrob. Agents. Chemother. 31 : 124-125, 1987.


  • Pecquet S, Ravoire S, Andremont A. Fecal excretion of Ciprofloxacin after oral administration of a single oral dose and its effect on fecal bacteria in healthy volunteers. J. Antimicrob. Chemother. 26 : 125-129, 1990.


  • Pecquet S, Chachaty E, Tancrède C, Andremont A. Effect of Roxithromycin on fecal bacteria in human volunteers and resistance to colonization in gnotobiotic mice. Antimicrob. Agents. Chemother. 35: 548-552, 1991.


  • Pecquet S, Guillaumin D, Tancrède C, Andremont A. Kinetics of  Saccharomyces cerevisiae elimination from the intestines of human volunteers  and effect of  this yeast on resistance to microbial colonization in gnotobiotic mice. Appl. Environ. Microbiol. 57 : 3049-3051, 1991.


  • Pecquet S, Andremont A, Tancrède C. Selective decontamination of the digestive tract by Norfloxacin. A preliminary report. In Progress in Clinical and Biological Research. Microflora Control and its Application to the Biomedical Science, vol.181, p.255-258. Editor B.S. Wostmann Inc., New York, 1984.


  • Pecquet S, Andremont A, Tancrède C. Les modifications de la flore digestive humaine dues aux fluoroquinolones. In Problèmes actuels de pathologie infectieuse et de réanimation. Les nouvelles quinolones, p. 207-211. J. Pocidalo, F. Vachon, B. Régnier. Edition Arnette, Paris, 1985.


  • Pecquet S, “Effet de l’acide nalidixique sur les fonctions de barrière d’une flore humaine. Etude en souris hétéroxéniques” Mémoire de D.E.A de Microbiologie, Université Paris XI, 1982.


  • Pecquet S, “Effet de trois quinolones sur la flore fécale de l’homme” Thèse de Doctorat de l’Université Paris XI, Mention Sciences Pharmaceutiques, 1985.

 3. Immunité et Vaccination Orale 


  • Le Roy D, Bouchet A, Saulnier P, Pecquet S, Andremont A. Comparison of chemical assay, bioassay, enzyme-linked immunosorbent assay, and dot-blot hybridization for detection of aerobactin in members of the family Enterobacteriaceae. Appl. Environ. Microbiol. 59 : 942-944, 1993. 


  • Lebrec H, Blot C, Pecquet S, Roger R, Bohuon C, Pallardy M. Immunotoxicalogical investigation using pharmaceutical drugs. I. In vivo evaluation if immune effects. Fundam. Appl. Tox. 23 : 159-168,1994

  • Balland O, Pinto-Alphandary H, Pecquet S, Andremont A, Couvreur P. The uptake of ampicillin-loaded nanoparticles by murine macrophages infected with Salmonella typhimurium. J. Antimicrob. Chemother. 33 : 509-522,1994


  • Allaoui-Attarki K, Pecquet S, Fattal E, Chachaty E, Couvreur P, Andremont A. Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-Lactide-Co-Glycolide) microspheres. Infect. Immun.  65 : 853-57, 1997


  • Allaoui-Attarki K,  Fattal E, Pecquet S, Chachaty E, Trollé S, Couvreur P, Andremont A. Mucosal immunogenicity elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-Lactide-Co-Glycolide) microspheres. Vaccine  16, 685-691, 1998


  • Léo E, Pecquet S, Couvreur P, Fattal E. Changing the pH of the extenal aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. J. Microencaps. 15, 421-430, 1998


  • Fattal E, Balland O, Alphandary H, Pecquet S, Puisieux F, Couvreur P, Andremont A. Colloïdal carriers for antibiotics as an alternating approach for the treatment of intracellular infections. In Antimicrobial Agents and Intracellular Pathogens.7V. Raoult Ed. CRC Press, London, 63-72, 1993.


  • Fattal E, Attarki K, Pecquet S, Blanco,  Puisieux F, Andremont A, Couvreur P. Oral vaccination by thyroglobulin-phosphorylcholine conjugate entrapped in PLA-GA microspheres. In Proceedings International Symposium of Controlled Release Bioactive Material . vol 21 . Controlled Release Society, Inc. 1994

4. Allergie et Tolerance Orale aux Antigènes Alimentaires


  • Fritsché R, Pahud JJ, Pecquet S, Pfeifer A. Induction of oral tolerance to B-Lactoglobulin by oral administration of a whey protein hydrolysat. J. Allergy Clin. Immunol. 100, 266-73, 1997


  • Pecquet S, Fritsché R, Gauldie S, Pfeifer A. IgE suppression and cytokine modulation in mice orally tolerised to B-lactoglobulin Immunology 96, 278-85,1999


  • Rojas J, Pinto-Alphandary H, Léo E, Pecquet S, Couvreur  P, Gulik A, Fattal E.  A polysorbate-based non ionic surfactant can modulate loading and realease of B-lactoglobulin entrapped in multiphase poly(DL-Lactide-co-glycolide) microspheres. Pharma.Res.16, 255-60, 1999


  • Rojas J, Pinto-Alphandary H, Léo E, Pecquet S, Couvreur P, Fattal E. Optimization of the encapsulation and release of B-lactoglobulin entrapped in poly(DL-lactide-co-glycolide)microspheres Int. J. Pharma 183, 67-71, 1999


  • Pecquet S, Fattal E, Leo E, Couvreur P, Fritsché R, Pfeifer A. Oral tolerance elicited in mice by B-lactoglobulin entrapped in biodegradable microspheres. Vaccine, 18, 1196-1202, 2000


  • Pecquet S, Fritsché R, Bovetto L, Pfeifer A.  a B-lactoglobulin tryptic hydrolysate and B-lactoglobulin peptides can induce specific oral tolerance in mice.  J. Allergy  Clin. Immunol. 105, 514-21,2000


  • Fattal E, Couvreur P, Pecquet S. Induction de tolérance orale chez la souris par administration de microsphères de poly(lactide-co-glycolide) contenant de la B-lactoglobuline Ann.Pharm. Fr. 60, 44-49, 2002


  • Fattal E, Pecquet S, Couvreur P, Andremont A., Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens Int. J. Pharma 242, 15-24, 2002


  • Prioult G, Fliss I, Pecquet S. Effect of probiotic bacteria on the induction and the maintenance of oral tolerance to B -lactoglobulin in gnotobiotic mice Clin. Diag. Lab. Immunol. 10, 787-792, 2003


  • Prioult G, Pecquet S, Fliss I. Stimulation of interleukin-10 production by acidic B -lactoglobulin-derived peptides hydrolysed with Lactobacillus paracasei NCC2461 peptidases Clin. Diag. Lab. Immunol. 11, 266-271, 2004


  • Pecquet S, Prioult G, Campbell J, German B, Turini M. Commonly used drugs impair oral tolerance in mice Ann. N.Y. Acad. Sci., 1029, 374-378, 2004


  • Prioult G, Pecquet S., Fliss I. Anti-allergic properties of Bifidobacterium lactis Bb12 against B-lactoglobulin  Int. J. Dairy, 15, 439- 448, 2005


  • Pecquet S, Chibani-Chennoufi S, Rochat F and Mercenier A.  Daily oral administration with Lactobacillus paracasei CNCM I-2116 leads to a down-modulation of milk protein hypersensitivity in mice. Reprod. Nutr. Dev. 2006, 46 (Suppl.1) S 73-74.


  • Turini M, German B, Campbell J, Prioult G, Pecquet S. Cox-2 inhibition may lead to allergy: a health concern? manuscript in preparation

5. Nutrition Maternelle et Infantile




  • Cohen R, Martin E, de La Rocque F, Thollot F, Pecquet S, Werner A, Boucherat M, Varon E, Bingen E, Levy C. Probiotics and prebiotics in preventing episodes of acute otitis media in high-risk children: a randomized, double-blind, placebo-controlled study. Pediatr Infect Dis J. Aug; 32(8):810-4, 2013

  • Billeaud C , Puccio G, Saliba E, Guillois B, Vaysse C, Pecquet S and Steenhout P.  Safety and tolerance evaluation of a milk fat globule membrane-enriched infant formulas: a randomized controlled multicenter non-inferiority trial in healthy term infants.  Clin.Med.Insights: Pediatrics, 14 (8) 51-60, 2014



  • Eigenmann P, Lauener R, Jung A, Pecquet S, Nutten S , Vissers Y, Sjölander S, Wassenberg J. Safety of specific oral tolerance induction (SOTI) with partially hydrolysed cereals in correlation to wheat –protein Ig E, JACI 135(2): AB28 Feb, 2015


  • Lee YL, Bharani R, Biswas A, Lee J, Tran LA, Pecquet S, Steenhout P. Normal growth of infants receiving an infant formula containing Lactobacillus reuteri, galacto-ologosaccharides, and fructo-oligosaccharides: a randomized controlled trial. Maternal Health, Neonatology and Perinatology 2015, 1:9 (7 April 2015)





  • Cooper P, Bolton K, Velaphi S, de Groot N, Emady-Azar S, Pecquet S, Steenhout P. Early benefits of a starter formula enriched in prebiotics and probiotics on the gut microbiota of healthy infants born from HIV+ mothers: a randomized double blind controlled trial, Clin. Med. Insights Pediatrics 10:119-130.  2017


  • Radke M, Picaud JC, Loui A, Cambonie G, Faas D, Lafeber H, de Groot N, Pecquet S, Steenhout P, Hascoet JM. A starter formula enriched in prebiotics and probiotics ensures normal growth of full terms infants and promotes gut health. Ped Research, 81: 622-31, 2017.


  • Bauer F, Singh A, Zötl B, Seng D, Pecquet S, Steenhout P, Nutten S, Bauer C. High tolerability of a rice- and carob-based cereal demonstrated in infants and children suffering from severe allergy: a randomized open-food challenge trial, J Allergy Ther,  7: 244-6,2017


  • Spalinger J, Nydegger A, Belli D, Furlano R, Yan J, Tanguy J, Pecquet S, Destaillats F, Egli D, Steenhout P. Growth of infants fed formulas with evolving nutrition composition: A single-arm non-inferiority study, Nutrients,  9,  219-31,  2017


  • Lauener R, Eigenmann P, Wassenberg J, Jung A, Denery-Papini S, Sjölander S,  Pecquet S, Fritsché R, Zuercher A, Wermeille A, Fontanesi M, Mercenier A, Vissers Y, Nutten S. Oral immunotherapy with partially hydrolyzed wheat-based cereals in wheat allergic infants, Clin.Med. Insights Pediatrics,Volume 11: 1–6, 2017 


  • Mantaring J, Benyacoub J, Destura R, Pecquet S, Vidal K , Volger S, Guinto V. A nutritional supplement beverage with and without probiotics during the third trimester of pregnancy and lactation improves growth in Filipino infants at 12 months of age: a RCT in the Philippines. BMC Pregnancy Childbirth. 2018; 18: 193.


  • Hughes-Formella B, Wunderlich O, Williams R, Fernández J, Kim Y, Wigger-Alberti W, Pecquet S, Moodycliffe A.. Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants. Skin Pharmacol Physiol. 2019;32(4):212–223.


  • Castanet M, J-M. Hascoet, P. Steenhout, B. Berger, N. Sprenger, D. Grathwohl, J-C. Roze, A. Pollak, N. Haiden, C. Costalos, H. Bruessow, N. De Groot, S. Pecquet, J. Benyacoub, J-C. Picaud, Effect of infant formula on growth, gut maturation and microbiota composition: A multicentric randomized controlled study, Nutrients 2020, 12, 1481-1501.

  • M.D. Cabana, E.E. Ziegler, R. Litov, S. Emady-Azar, N. De Groot, S. Pecquet, H. Storm, J. Saavedra, Partially hydrolyzed whey infant formulas with lower protein levels support adequate growth and development: a randomized clinical trial, submitted to Clin Med Insights Pediatrics.


  • U. Vaidya, A. Bavdekar, A. Ghosh, M. Mitra, R. Agrawal, A. Narang, E. Adarsh , S. Pecquet, S. Ganguly  Safety and tolerance of infant formulas containing probiotics in India: a multicenter randomized controlled trial.  Manuscript in prep.

  • Sauser J, Nutten S, de Groot N., Pecquet S, Simon D, Simon H-U, Spergel JM, Koletzko S, Blanchard, C. Partially Hydrolyzed Whey Infant Formula: Literature Review on Effects on Growth and the Risk of Developing Atopic Dermatitis in Infants from the General Population Int Arch Allergy Immunol. 2018 Sep; 177(2): 123–134

2. Immunité des Muqueuses

  • Ernst PB and Pecquet S. Interactions between Helicobacter pylori and the local immune system. Scand. J. Gastroenterology. 26 : 56-64, 1991.


  • Pecquet S, Ehrat C, and Ernst P. Enhancement of mucosal antibody response to Salmonella typhimurium and the microbial hapten phosphorylcholine in mice with X-linked immunodeficiency by B cell precursors from the peritoneal cavity. Infect. Immun. 60 : 503-509, 1992.


  • Pecquet S, Zazulak J, Simpson S, Ernst P. Reconstitution of Xid mice with donor cells enriched for CD5+B cells restores contrasuppression. Ann. N.Y. Acad. Sci. 651 : 173- 175, 1992.


  • Simpson S, Pecquet S, Ernst P.  Xid mice lack regulatory immunoglobulin which contributes to enhancement of SRBC responses. Ann. N.Y. Acad. Sci. 651 : 179-181, 1992.


  • Pecquet S, Zazulak J, Marshall J, and Ernst PB. Characterization of regulatory immunoglobulin in molecular interactions that initiate a contrasuppression of isotype specific antibody response. In  EOS J.Immonol.Immunopharmacol. IX (3):139, Rome, Italy, 1989.


  • Ernst PB , Croitoru K, Zettel L, and Pecquet S. Response of IEL and Peyer’s patches  lymphocytes to oral immunization. In Proceedings of the Ninth World Congress of Gastroenterology   Satellite Symposium on Mucosal Immunology, Sydney, Australia, Ed A.W. Cripps, Newey & Beath, Newcastle, pp.113-118, 1991.

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